师资队伍

相关链接:

科研成果 学院主页

引进人才

Profile


 
 
 
 
 

Name

Kevin H. Mayo

Gender

Male

Date of Birth

18 January 1955

Nationality

American/USA

Highest Degree

Ph.D

Professional Position

Professor

Education/

Training/Employment

Period

Graduate   school/Institution

Field of   Study

Degree/Position

1972-1976

Boston   University

Chemistry   and Biology

B.A.

1976-1980

University   of Massachusetts

Chemistry   and Biochemistry

Ph.D

1980-1982

Technical   University of Munich

Physics

Post-doctoral   Fellow

1980-1982

Max Planck   Institute

(von   Humboldt Fellowship)

Fellowship

Biochemistry

Post-doctoral   Fellow

1982-1984

Yale   University

Chemistry

Post-doctoral   Fellow

1984-1988

1988-1991

Temple   University

Chemistry

Assistant   Professor

Associate   Professor

1991-1993

Jefferson College of Medicine

Structural   biology

Associate   Professor

1993-present

University   of Minnesota

Biochemistry,   Molecular Biology & Biophysics

Professor

Academic   Honors & Social Services

   Alexander   von Humboldt Fellowship at the Max Planck Institute for Biochemistry &   The Technical University of Munich, Germany

   Director   of the High Field NMR Facility at the University of Minnesota

   Member   of US National Science Foundation Advisory Panel on Biophysics

   Member/Chair   of US National Institutes of Health Scientific Review Panels for General   Medical Sciences and National Cancer Institute

   Deputy   Chair of the Biochemical Journal

   Editorial   Board/Reviewer for: J. Biol. Chem., Biochemistry, Cancer Research, Proc.   Natl. Acad. Sci. USA, J. Am. Chem. Soc.; J. Biol. NMR., Biochem. J., J. Phys.   Chem., Protein Sci., Folding & Design, FASEB Journal, Pharmaceuticals,   Medicinal Chemistry, Nature, Cell.

   Board   Member of PepTx, Inc., Boston Therapeutics, and Galectin Therapeutics, as   well as consultant to several pharmaceutical companies.


 


 
 

Academic   Achievements

1984-1988        Assistant   Professor, Department of Chemistry, Temple University

1988-1991        Associate   Professor, Department of Chemistry, Temple University

1990-1991        Fels   Cancer Research Institute, Temple University

1991-1993      Associate Professor, Departments of Molecular Pharmacology   and                                                                       Biochemistry   and Molecular Biology, Jefferson Cancer Institute,

                Thomas Jefferson University

1993-1998   Associate   Professor, Departments of Biochemistry, Molecular Biology & Biophysics,   and

Lab Medicine and Pathology, and Biomedical Engineering,   University of Minnesota,

Minneapolis, MN

1998-           Professor, Departments of   Biochemistry, Molecular Biology & Biophysics, and Lab

Medicine and Pathology, and   Biomedical Engineering, University of Minnesota,

Minneapolis, MN

1993-1998       Director,   High Field NMR Facility, University of Minnesota.

1996-            Member, Center for Bio-Interfacial Engineering, University of Minnesota.

1997-            Member, NCI Comprehensive Cancer Center, University of Minnesota.

2003-            Fellow, Supercomputing Institute, University of Minnesota

2013         Wellens Visiting   Professorship, Maastricht University, Department of  

                Biochemistry, The Netherlands

2014-           Visiting Professor at   Ludwigs-Maximaillian-University, Cardiovascular   Research                

                Institute, Munich, Germany

Dr. Mayo has over 35 years experience as an   academic researcher, teacher, and consultant to the pharmaceutical industry.   Dr. Mayo’s research interests lie in the areas of nuclear magnetic resonance   (NMR) spectroscopy, protein & carbohydrate structural biology, protein   dynamics using NMR relaxation and MD simulations, and pharmaceutical drug   discovery. Dr. Mayo is the author of over 190 peer-reviewed scientific   publications and 18 patents, as well as being PI on research grants from the   National Institutes of Health and Pharmaceutical Industry.

Publications:

Thijssen, V.L.J.L.,   Postel, R., Brandwijk, R.J.M.G.E., Dings, R.P.M., Nesmelova, I., Satijn, S.,   Verhofstad, Nakabeppu, Y., Baum. L.G., Bakkers, J., MAYO, K.H., Poirier, F.,   and Griffioen, A.W.“Galectin-1 is essential in tumor angiogenesis and is a   target for anti-angiogenesis therapy” Proc. Natl. Acad. Sci. USA  103,   15975-15980 (2006).

Kronen, R., von Hundelhausen, P., Nesmelova, I.V.,   Zernecke, A., Liehn, E.A., Sarabi, A., Kramp, B.K., Piccinini, A., Paludan,   S.R., Kowalska, M.A., Kungl, A.J., Hackeng, T.M., MAYO, K.H., and Weber, C.   “Disrupting functional interactions between platelet chemokines inhibits   atherosclerosis in hyperlipidemic mice” Nature Med. 15, 97-103 (2009).

Nesmelova, I.V.,   Ermakova, E., Daragan, V.A., Pang, M., Menendez, M., Lagartera, L.,

Solis, D., Baum, L.G.,   MAYO, K.H. “Lactose binding to galectin-1 modulates structural dynamics,   increases conformational entropy, and occurs with apparent negative   cooperativity” J. Mol. Biol. 397, 1209-1230 (2010).

Dings, R.P.M., Miller,   M.C., Nesmelova, I., Astorgues-Xerri, L., Kumar, N., Serova, M.,

Chen, X.,  Raymond,   E., Hoye, T.R., and MAYO, K.H.“Anti-tumor agent calixarene 0118 targets human   galectin-1 as an allosteric inhibitor of carbohydrate binding,” J. Med. Chem.   55,   5121-5129 (2012).